ABSTRACT
Aim: To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with coronary artery disease (CAD).
Methods: This cross-sectional, clinical study was performed on 194 CAD patients and 114 controls in the cardiology department of our tertiary care center. Descriptive data (age, gender, body-mass index, smoking habit) were noted and biochemical parameters (haemoglobin, hematocrit, serum levels of glucose, lipids, creatinine, mean platelet volume) were evaluated. Genotyping was made for investigating the association of G14713A and T29107A polymorphisms of Caveolin-1 with CAD.
Results: Positivity for Caveolin T29107A was detected significantly more frequently in CAD patients, (p=0.009), while such a difference could not be observed for Caveolin G14713A (p=0.064). Coronary artery disease patients had higher body mass indices, mean platelet volumes, serum levels of blood glucose, cholesterol, triglycerides, low-density lipoproteins, creatinine compared to the control group.
Conclusions: In conclusion, our results have shown that T29107A specific genotype of Caveolin-1 may be linked with CAD pathogenesis. Utility of this polymorphic variant as a diagnostic or prognostic marker in CAD warrants further trials on larger series.
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