H Erdogan

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

Issue:

Vol 70, Issue 1: 2023

DOI:

10.7727/wimj.2016.106

Pages:

61-8

Synopsis:

Leptin and endothelin (ET), as important endogenous factors, interact with each other which may contribute to a better understanding of their role in diabetic pathogenesis. We aimed to evaluate the relationship between leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on leptin levels in rats with diabetes induced by streptozotocin (STZ). In this study, 24 male, Wistar-albino rats were divided into three groups: Control, STZ, STZ + BQ-123 groups. BQ-123 relatively reduced oxidative stress and leptin levels. ETAR antagonist BQ-123 has positive impacts, depending on the dosage in the diabetic rats.

ABSTRACT

Objective: Leptin and endothelin (ET) as important endogenous factors interacting with each other which may contribute to a better understanding of their role in diabetic pathogenesis. We aimed to evaluate the relationship between leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on leptin levels in rats with diabetes induced by streptozotocin (STZ).

Received:

10 Mar, 2016

Accepted:

25 May, 2016

Published:

29 Nov, 2023

PDF Attachment:

wimj-iss1-2023_61_68.pdf

Journal Sections:

Original Articles

Keywords:

BQ-123

endothelin-1

experimental diabetes

Journal Authors:

e-Published: 07 Jul, 2016

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Periorbital Ecchymosis (Racoon Eyes): A Case of a Primary Systemic Amyloidosis

DOI:

10.7727/wimj.2016.197

ABSTRACT

Received:

02 May, 2016

Accepted:

15 Jun, 2016

PDF Attachment:

demir20et20al-primary20systemic20amyloidosis1.pdf

Journal Sections:

Case Reports

Keywords:

Amyloidosis

primary systemic amyloidosis

Journal Authors:

e-Published: 30 Jun, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Investigation of Paraoxanase Enzyme Polymorphism in Patients with Alopecia Areata

DOI:

10.7727/wimj.2015.491

Synopsis:

We investigated the relationship between alopecia areata (AA) and polymorphisms of paraoxanase 1 (PON1). Although the frequency of PON 55 L allel was higher in the patient group than control, there was no relation between the AA and both PON1 M/L55 and R/Q192 polymorphism.

ABSTRACT

Objective: In this study, we investigated the relationship between AA and genetic polymorphisms of PON1 R192Q and PON1 L55M.

Methods: One hundred and nineteen patients with AA and 104 healthy controls were included in this study. The changes in aminoacid squencies on codon 55 and 192 were analysed by the polymerase chain reaction and restriction enzymes.

Received:

07 Sep, 2015

Accepted:

30 Sep, 2015

PDF Attachment:

gurel_et_al-investigation_of_paraoxanase_enzyme_polymorphism_in_patients_with_alopecia_areata_text.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 15 Mar, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Protective Effects of Curcumin Against Formaldehyde-induced Renal Toxicity in Rats

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.385

Pages:

338-44

Synopsis:

We explored the protective effects of curcumin against renal injury induced by formaldehyde in rats and found that it improved the formaldehyde-induced renal degeneration.

ABSTRACT

Objective: To explore the protective effects of curcumin against renal injury induced by formaldehyde in rats.

Received:

13 Jul, 2015

Accepted:

10 Sep, 2015

Published:

12 Nov, 2021

PDF Attachment:

wimj-iss5-2021_338_344.pdf

Journal Sections:

Original Articles