In metastatic gastric cancer (MGC), the goals of treatment are palliation and prolongation of overall survival. Systemic chemotherapy, with docetaxel, cisplatin, infusional 5-fluorouracil (DCF) are a commonly used regimen in MGC as first line chemotherapy with a low tolerability rate due to its toxicity. We evaluated the efficacy and tolerability of weekly DCF compared to standard DCF regimen.