M Gossell-Williams

Gentamicin Therapeutic Drug Monitoring: Importance in the Hospital Setting

Issue:

Vol 66, Issue 2: 2017

DOI:

10.7727/wimj.2015.603

Pages:

324–8

Synopsis:

Gentamicin has a propensity to induce nephrotoxicity. This study showed that most of the patients treated with gentamicin experienced some levels of nephrotoxicity and suggests the need for the vigilant monitoring of serum creatinine in such patients in a hospital setting without therapeutic drug monitoring facilities.

ABSTRACT

Background: Use of gentamicin places patients at risk of developing drug-induced nephrotoxicity, requiring special consideration to be given to serum creatinine monitoring and therapeutic drug monitoring (TDM).

Objectives: To evaluate the prevalence of nephrotoxicity without the availability of TDM.

Received:

10 Dec, 2015

Accepted:

02 Feb, 2016

Published:

22 Sep, 2017

PDF Attachment:

wimj-iss2-2017_324_328.pdf

Journal Sections:

Original Articles

Keywords:

gentamicin

therapeutic drug monitoring

Journal Authors:

e-Published: 31 Mar, 2016

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A Review of Pharmacovigilance

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2013.251

Pages:

771–4

Synopsis:

Spontaneous reporting of adverse drug reactions (ADRs) is an essential component of pharmacovigilance, but the safe and appropriate use of drugs is limited by under-reporting of ADRs. Knowledge of pharmacovigilance could form the basis for interventions aimed at improving reporting rates.

ABSTRACT

Pharmacovigilance supports safe and appropriate use of drugs. Spontaneous reporting of adverse drug reactions (ADRs) is an essential component of pharmacovigilance. However, there is significant underreporting of ADRs. Adverse drug reactions have become a major problem in developing countries. Knowledge of pharmacovigilance could form the basis for interventions aimed at improving reporting rates and decreasing ADRs.

Received:

17 Sep, 2013

Accepted:

27 Sep, 2013

PDF Attachment:

wimjdec2014_771_774.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 05 Mar, 2015

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A Case for a Holistic Approach to the Improvement of Compliance among Hypertensive Patients: A Hospital Review

Issue:

Vol 63, Issue 3: Emergency Medicine (2014)

DOI:

10.7727/wimj.2013.156

Pages:

271–3

Synopsis:

A recent survey of hypertensive patients at the Emergency Department of the University of the West Indies revealed that more than a third were non-compliant with their prescribed medications and more than half had poorly controlled blood pressure. Providing access to drug is inadequate and a more holistic approach is required to reduce blood pressure on the population level.

ABSTRACT

Received:

09 May, 2013

Accepted:

16 May, 2014

PDF Attachment:

gossell-williams_et_al-compliance_among_hypertensive_patients.pdf

Journal Sections:

Viewpoint

Keywords:

Hypertension

Antihypertensive medications

Journal Authors:

e-Published: 12 Jun, 2014

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Monoclonal Antibodies in Cancer Therapy: Mechanisms, Successes and Limitations

Issue:

Vol 63, Issue 6: Oct (2014)

DOI:

10.7727/wimj.2013.241

Pages:

650–4

Synopsis:

The classification, efficacy and significantly reduced toxicity of chemotherapeutic monoclonal antibodies (CmAbs) available for use in the United States of America are presented, and their limitations and future considerations are explored.

ABSTRACT

Received:

05 Sep, 2013

Accepted:

24 Feb, 2014

PDF Attachment:

coulson_et_al-monoclonal_antibodies_in_cancer_therapy.pdf

Journal Sections:

Keywords:

monoclonal antibodies

Journal Authors:

A Coulson

A Levy

M Gossell-Williams

e-Published: 29 May, 2014

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The Use of Analgesic Drugs in Patients with Sickle Cell Painful Crisis

Issue:

Vol 63, Issue 5: Sep (2014)

DOI:

10.7727/wimj.2012.272

Pages:

479–83

Synopsis:

Painful crisis in patients with sickle cell anaemia is associated with severe pain in 75% and most will require second line therapy for adequate resolution. Physicians need to provide adequate pain relief to decrease morbidity in these patients.

ABSTRACT

Objective: To determine the drug options used for pain in patients with acute sickle cell painful crisis at the University Hospital of the West Indies (UHWI), Jamaica.

Method: This retrospective study assessed all patients admitted to the UHWI between January 1, 2006 and December 31, 2010 with acute sickle cell anaemia painful crisis and the data obtained regarding site, severity, outcome and drug options selected for pain.

Received:

08 Oct, 2012

Revised:

24 Feb, 2013

Accepted:

12 Mar, 2013

PDF Attachment:

boyd_et_al-analgesic_drugs_and_sickle_cell_anaemia.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 30 Apr, 2014

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Suicide Attempt by Self-poisoning: Characteristics of Suicide Attempters Seen at the Emergency Room at the University Hospital of the West Indies

Issue:

Vol 61, Issue 5 (2012) - Special Issue on Mental Health

Pages:

526–31

Synopsis:

Of the sample of 127 patients seen for attempted suicide by self-poisoning, 75.6% were females. The age cohort 16–30 years represented the largest number of cases (70.8%).

ABSTRACT

Objective: To document the characteristics of self-poisoning suicide attempters who were brought to the University Hospital of the West Indies (UHWI) Emergency Room and to outline the type of drug used in the attempt.

PDF Attachment:

dr_j_williams-johnson.qxd_.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 24 Oct, 2013

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Hypoglycaemic Complications of Diabetes Mellitus Management: The Predominant Adverse Drug Reaction Presenting to the Accident and Emergency Department of The University Hospital of The West Indies

Issue:

Vol 59, issue 5 (2010)

Pages:

555–60

Synopsis:

Drug-induced hypoglycaemia among patients with diabetes mellitus accounted for 56.3% of the adverse drug reactions cases and most of the patients had comorbidities and were on multi-drug therapy.

ABSTRACT

PDF Attachment:

dr_gossell-williams.qxd_.pdf

Journal Sections:

Original Articles

Keywords:

diabetes mellitus

adverse drug reactions

drug-induced hypoglycaemia

Journal Authors:

M Gossell-Williams

J Williams-Johnson

L Francis

e-Published: 15 Oct, 2013

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Pharmacovigilance: Healthcare Professionals’ Role in Benefits versus Harm Analysis of Drugs Use

Issue:

Vol 59, issue 1 (2010)

Pages:

73–5

Synopsis:

It is the responsibility of all healthcare professionals to participate in ‘pharmacovigilance’. This review aims to sensitize Caribbean healthcare professionals to what is Pharmacovigilance and how their active involvement is imperative to the benefit versus harm evaluation of drugs.

ABSTRACT

PDF Attachment:

dr_m_gossell-williams_wimj_january1.qxd_.pdf

Journal Sections:

Original Articles

Keywords:

Pharmacovigilance

adverse drug reactions

healthcare professionals

adverse drug events

Journal Authors:

M Gossell-Williams

e-Published: 01 Oct, 2013

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Preference of Patient Information Leaflets over Standard Drug Monographs by Patients Prescribed Hydrochlorothiazide, Nifedipine and Enalapril

Issue:

Vol 61, issue 3 (2012)

Pages:

271–9

Synopsis:

There is benefit in designing patient information leaflets that simplify language and medication information contained in standard drug monographs, including better understanding of precautions to take while on medication and when to consult physicians.

ABSTRACT

PDF Attachment:

dr_m_gossell-williams_wimj.qxd_.pdf

Journal Sections:

Original Articles

Keywords:

Antihypertensives

patient information leaflet

standard drug monograph

Journal Authors:

M Gossell-Williams

O Bennett